线粒体功能困难在多种神经系统疾病中饰演要道脚色。在蛛网膜下腔出血中，缺血缺氧导致线粒体功能受损，开释大批活性氧和炎症介质，激活凋一火通路，而线粒体质地截止机制是潜在调治靶点。在亨廷顿病中，CAG重迭扩增导致线粒体能量代谢困难、生物发生超过、运载受阻及钙稳态失调。脊髓毁伤后，线粒体稳态龙套影响ATP产生，窒碍轴突再生与开发，开云sports规复线粒体功能可促进神经功能规复。在阿尔茨海默病中，线粒体功能困难与脑葡萄糖代谢缩短密切有关，葡萄糖缺少导致O-GlcNAcylation水平窜改，进而影响线粒体功能。

线粒体蚁集能源学颓势、氧化磷酸化超过及活性氧过度产生是这些疾病的共同病理机制，针对线粒体生物发生、能源学均衡、运载功能及代谢超过的侵略政策为神经系统疾病调治提供了新场地。

因此，特精选本刊2023-2024年发表的线粒体功能困难在神经系统疾病中的作用操办的热门综述著作5篇，供读者参阅。

(1) Mitochondrial dysfunction and quality control lie at the heart of subarachnoid hemorrhage

线粒体功能困难和质地截止是蛛网膜下腔出血的中枢所在

援用本文：

Zhang J， Zhu Q， Wang J， Peng Z， Zhuang Z， Hang C， Li W. Mitochondrial dysfunction and quality control lie at the heart of subarachnoid hemorrhage. Neural Regen Res. 2024;19(4):825-832.

正文说合:

https://journals.lww.com/nrronline/fulltext/2024/04000/mitochondrial_dysfunction_and_quality_control_lie.27.aspx

(2) Crosslink between mutations in mitochondrial genes and brain disorders: implications for mitochondrial-targeted therapeutic interventions

线粒体基因突变与脑部疾病之间的交叉联系：线粒体靶向调治侵略的真谛

援用本文：

Kalra J. Crosslink between mutations in mitochondrial genes and brain disorders: implications for mitochondrial-targeted therapeutic interventions. Neural Regen Res. 2023;18(1):94-101.

正文说合:

https://journals.lww.com/nrronline/fulltext/2023/01000/crosslink_between_mutations_in_mitochondrial_genes.14.aspx

(3) Mitochondria in Huntington's disease: implications in pathogenesis and mitochondrial-targeted therapeutic strategies

亨廷顿氏病中的线粒体：对发病机制和线粒体靶向调治政策的影响

援用本文：

Jurcau A， Jurcau CM. Mitochondria in Huntington's disease: implications in pathogenesis and mitochondrial-targeted therapeutic strategies. Neural Regen Res. 2023;18(7):1472-1477.

正文说合:

https://journals.lww.com/nrronline/fulltext/2023/07000/mitochondria_in_huntington_s_disease__implications.12.aspx

(4) Mitochondrial dysfunction as a target in spinal cord injury: intimate correlation between pathological processes and therapeutic approaches

脊髓毁伤中线粒体功能困难看成靶点：病理经过与调治政策的密切关联

援用本文：

Schmidt J， Quintá HR. Mitochondrial dysfunction as a target in spinal cord injury: intimate correlation between pathological processes and therapeutic approaches. Neural Regen Res. 2023;18(10):2161-2166.

正文说合:

https://journals.lww.com/nrronline/fulltext/2023/10000/mitochondrial_dysfunction_as_a_target_in_spinal.10.aspx

(5) Altered O-GlcNAcylation and mitochondrial dysfunction， a molecular link between brain glucose dysregulation and sporadic Alzheimer's disease

O-GlcNAcylation窜改与线粒体功能困难——脑葡萄糖波折失常与自在性阿尔茨海默病间的分子关联

援用本文：

Huang CW， Rust NC， Wu HF， Hart GW. Altered O-GlcNAcylation and mitochondrial dysfunction， a molecular link between brain glucose dysregulation and sporadic Alzheimer's disease. Neural Regen Res. 2023;18(4):779-783.

正文说合:

https://journals.lww.com/nrronline/fulltext/2023/04000/altered_o_glcnacylation_and_mitochondrial.14.aspx

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